German China
Particles of the H1N1 influenza virus. (Helmholtz Centre for Infection Research (HZI))
Germany: Immunology

Crucial Role of Receptor in Defensive Response to Influenza

When influenza viruses enter our body, the immune system recognises them as being foreign by means of various receptors and starts a defence programme.Scientists of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and of the Otto von Guericke University Magdeburg recently studied the detailed role of a certain receptor in this first line of defence. They discovered that the receptor activates natural killer cells, which use messenger substances to activate other immune cells and then eliminate body cells that are infected by viruses.

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Mathias Wilhelm (l.) and Professor Bernhard Küster (r.) in discussion about the ProteomeTools Peptide Library called PROPEL. (Andreas Heddergott/ TUM)
Germany: ProteomeTools

Library of the Human Proteome

Researchers led by the Technical University of Munich (TUM) report on the synthesis of a library of more than 330,000 reference peptides representing essentially all canonical proteins of the human proteome. This research is a major milestone in the ProteomeTools project which aims at translating human proteome information into new molecular and digital tools with the potential for use in drug discovery, personalized medicine and life science research.

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3D structure of an NRPS docking domain pair. The docking domains of NRPS B (green) connects to the fitting docking domain of NRPS C (magenta) via a β-leaflet. (J.-W.-Goethe Universität Frankfurt am Main)
Germany: Biosynthesis

Custom-Designed Natural Products Within Reach

Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists at Goethe University have now been able to discover how these enzymes interact with each other. This brings them one step closer to their goal of engineering the production of such peptide natural products.

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