Led by Dr. Manoj Kumar Bhat, a team of Indian researchers from the National Centre for Cell Science conducted studies on laboratory-bred mice to determine if obesity resulting from leptin deficiency could have any influence on cancer. The study provided valuable insights into the molecular connections underlying the relationship of diet-induced and genetics-associated obesity with colon cancer.
The findings warrant further exploration through more in-depth clinical studies, to determine if they have any implications in and relevance to the management of cancers.
(Source: Deposit Photos)
Delhi/India – Obesity per se does not cause cancer but the behaviour and prognosis of cancer can vary depending on whether or not the cancer patient is co-morbidly obese. Many different factors can cause obesity. One of the major reasons is genetic in nature. A mutation or small changes in the DNA can make one obese by making an important signalling pathway called the leptin signalling pathway non-functional. Leptin signalling pathway is involved in regulating food intake, energy consumption and body fat content, by mediating communication of the gut and fat cells with the brain.
To determine whether obesity resulting from leptin deficiency could have any influence on cancer, Dr. Manoj Kumar Bhat and his research team at the National Centre for Cell Science (NCCS) in Pune studied the differences in the incidence and progression of colon cancer when it occurs in association with genetically-linked obesity, vis-a-vis when it occurs in association with diet-induced obesity.
Their studies in laboratory-bred mice revealed significant differences between these two groups. Further, these differences were found to be strongly correlated with the balance between two important molecules, leptin and TNF alpha, which influence the growth of cancer cells. These studies were carried out with approval from the Institutional Animal Ethics Committee, following humane and ethical procedures as per the applicable rules.
They have provided valuable insights into the molecular connections underlying the relationship of diet-induced and genetics-associated obesity with colon cancer. These findings warrant further exploration through more in-depth clinical studies, to determine if they have any implications in and relevance to the management of cancers.
Unfold for details of your consent
Stand vom 23.03.2021
Naturally, we always handle your personal data responsibly. Any personal data we receive from you is processed in accordance with applicable data protection legislation. For detailed information please see our privacy policy.
Consent to the use of data for promotional purposes
I hereby consent to Vogel Communications Group GmbH & Co. KG, Max-Planckstr. 7-9, 97082 Würzburg including any affiliated companies according to §§ 15 et seq. AktG (hereafter: Vogel Communications Group) using my e-mail address to send editorial newsletters. A list of all affiliated companies can be found here
Newsletter content may include all products and services of any companies mentioned above, including for example specialist journals and books, events and fairs as well as event-related products and services, print and digital media offers and services such as additional (editorial) newsletters, raffles, lead campaigns, market research both online and offline, specialist webportals and e-learning offers. In case my personal telephone number has also been collected, it may be used for offers of aforementioned products, for services of the companies mentioned above, and market research purposes.
In case I access protected data on Internet portals of Vogel Communications Group including any affiliated companies according to §§ 15 et seq. AktG, I need to provide further data in order to register for the access to such content. In return for this free access to editorial content, my data may be used in accordance with this consent for the purposes stated here.
Right of revocation
I understand that I can revoke my consent at will. My revocation does not change the lawfulness of data processing that was conducted based on my consent leading up to my revocation. One option to declare my revocation is to use the contact form found at https://support.vogel.de. In case I no longer wish to receive certain newsletters, I have subscribed to, I can also click on the unsubscribe link included at the end of a newsletter. Further information regarding my right of revocation and the implementation of it as well as the consequences of my revocation can be found in the data protection declaration, section editorial newsletter.