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France: Mass Spectrometry

LC-MS Routine Analysis for Novices and Experts

| Editor: Alexander Stark

Thermo Scientific ISQ EM single quadrupole mass spectrometer with the Thermo Scientific Vanquish UHPLC system
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Thermo Scientific ISQ EM single quadrupole mass spectrometer with the Thermo Scientific Vanquish UHPLC system (Source: Thermo Fisher Scientific)

Thermo Fisher offers a new technology for single quadrupole mass spectrometer. The system is designed for ease-of-use while offering application flexibility and reliable results for challenging mass confirmation analyses, the company says.

Cannes-Mandelieu/France — The Thermo Scientific ISQ EM single quadrupole mass spectrometer is designed for high performance and productivity standards in laboratories. With a mass range of 10–2,000 m/z, the system offers the power to detect and quantify small and large molecules, and supports analytical needs across an extensive range of applications — from drug development to manufacturing support and quality control. The system’s high-performing heated electrospray ionization (HESI) and dual HESI/atmospheric pressure chemical ionization (APCI) probes facilitate the measurement of polar and non-polar analytes, enabling application flexibility.

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According to the company, the ISQ EM enables novice and expert mass spectrometry users to take advantage of the technique’s excellent sensitivity and selectivity for the rapid and reliable analysis of complex sample matrices. Additionally, the single quadrupole mass spectrometer allowed cromatographers to obtain substantial information from routine samples, and thereby permits single assay runs, reliably tracks emerging impurities and quickly confirms the mass of newly synthesized entities.

The ISQ EM is integrated with HPLC systems and fully controlled by Thermo Scientific Chromeleon Chromatography Data System (CDS), which offers tools to guide users through LC-MS method development and select appropriate source conditions. Thermo Scientific Chromeleon XPS Open Access software also supports the ISQ EM with walk-up workflows for simple daily operation. Additionally, full integration with native control in Chromeleon CDS enables users to benefit from the entire productivity suite, from method creation through final reporting. A built-in reference standard also automates instrument calibration for a user-friendly experience.

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