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Whole-body 3D reconstruction
 (Source: Ali Ertürk Lab/ Helmholtz Munich)
Mouse Mapper

AI Platform Reveals Hidden Nerve Damage Linked to Obesity

Researchers have developed an AI-based platform that can map disease-related changes across the entire mouse body at cellular resolution. Using Mouse Mapper, the team identified widespread inflammation and previously unknown obesity-related damage to facial sensory nerves, and it found corresponding molecular signatures in human tissue.

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When combined with high content imaging and quantitative analysis tools, organotypic 3D microtissue models offer a scalable, reproducible, and human-relevant platform for evaluating therapeutic efficacy and safety. (Source: © JP STUDIO LAB - stock.adobe.com)
Industry Insights

Integrating Organotypic 3D Microtissue Models with Analytics to Advance Predictive Drug Development

Despite substantial investment in pharmaceutical R&D, clinical success rates remain low. As it stands, 90 % of drug candidates entering human trials fail due to unforeseen toxicity or limited efficacy in humans. A key contributor to this attrition is the limited predictive power of traditional preclinical models, particularly 2D cell cultures and animal studies, which often fall short in recapitulating the complexity of human biology. This gap is particularly evident in oncology and organ-specific toxicity assessments, where cellular context and microenvironmental interactions play a critical role in drug response.

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pH measurement in various nanoparticles using the Nine-Focus meter ensures precise stability and performance control. (Source: Mettler Toledo)
Drug Delivery

Tumor Trap: pH-Triggered Therapy

The precise pH monitoring is crucial for the stability and performance of nanoparticles in drug delivery. Read how these biocompatible materials are developed and at what step the pH measurement is incorporated into the process.

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