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Metastatic BAP1-deficient melanoma is the most common intraocular malignancy in adults, but it remains rare and extremely difficult to treat once it spreads.  (Source: Turun yliopisto/University of Turku)
Lab Tools

New Lab Model to Study Rare and Deadly Melanomas

Researchers have developed a new laboratory model to study rare tumors—BAP1-deficient melanomas—that are resistant to immunotherapies. The model has the potential to transform how therapies are developed for aggressive melanomas that currently have almost no effective treatment options.

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Galleries

When combined with high content imaging and quantitative analysis tools, organotypic 3D microtissue models offer a scalable, reproducible, and human-relevant platform for evaluating therapeutic efficacy and safety. (Source: © JP STUDIO LAB - stock.adobe.com)
Industry Insights

Integrating Organotypic 3D Microtissue Models with Analytics to Advance Predictive Drug Development

Despite substantial investment in pharmaceutical R&D, clinical success rates remain low. As it stands, 90 % of drug candidates entering human trials fail due to unforeseen toxicity or limited efficacy in humans. A key contributor to this attrition is the limited predictive power of traditional preclinical models, particularly 2D cell cultures and animal studies, which often fall short in recapitulating the complexity of human biology. This gap is particularly evident in oncology and organ-specific toxicity assessments, where cellular context and microenvironmental interactions play a critical role in drug response.

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