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When combined with high content imaging and quantitative analysis tools, organotypic 3D microtissue models offer a scalable, reproducible, and human-relevant platform for evaluating therapeutic efficacy and safety. (Source: © JP STUDIO LAB - stock.adobe.com)
Industry Insights

Integrating Organotypic 3D Microtissue Models with Analytics to Advance Predictive Drug Development

Despite substantial investment in pharmaceutical R&D, clinical success rates remain low. As it stands, 90 % of drug candidates entering human trials fail due to unforeseen toxicity or limited efficacy in humans. A key contributor to this attrition is the limited predictive power of traditional preclinical models, particularly 2D cell cultures and animal studies, which often fall short in recapitulating the complexity of human biology. This gap is particularly evident in oncology and organ-specific toxicity assessments, where cellular context and microenvironmental interactions play a critical role in drug response.

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Sterility testing failure is not an option for organizations that are committed to protecting both human and business health. (Source: © Andrey - stock.adobe.com)
Smart Notes

Creating Robust Sterility Testing Processes

Sterility testing is a crucial part of pharmaceutical manufacturing, and the consequences of non-compliance can be fatal. It is, however, a time- and resource- hungry process, needing to be carried out under aseptic conditions by specialized staff according to detailed protocols.

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