Gene editing could help solve one of the biggest problems in treating aggressive blood cancers: how to attack cancer cells without destroying healthy donor cells. A new multicentre trial shows that CRISPR-modified stem cell transplants may make CD33-targeted therapies safer and more effective after transplantation.

Psychiatrists assessing the same written patient cases agreed on a diagnosis only 55% of the time in an international study. The findings highlight persistent differences in how clinicians interpret symptoms, raising questions about diagnostic consistency and its implications for patient care and research.

Researchers have developed a new laboratory model to study rare tumors—BAP1-deficient melanomas—that are resistant to immunotherapies. The model has the potential to transform how therapies are developed for aggressive melanomas that currently have almost no effective treatment options.

Nearly half of dementia cases could be prevented by tackling modifiable risk factors such as physical inactivity, smoking, low education or social isolation, but new Curtin University research suggests current public health approaches are falling short of driving real behaviour change.

A gene shared by salamanders, zebrafish and mice could point toward a new path for regenerative medicine: researchers have identified key genetic programs involved in regrowth and used them to partially restore digit regeneration in mice. The findings do not bring human limb regeneration within immediate reach, but they offer a promising proof of principle for future gene-based therapies.

The determination of volatile organic compounds (VOCs) in postharvest analysis using gas chromatography coupled with mass spectrometry (GC–MS) has proven to be a suitable tool for predicting the extent of chilling injury and minimizing food losses. The peach example presented here may serve as a model case for other commodities.

Regular exercise can significantly reduce symptoms of depression and anxiety — in many cases as effectively as medication or psychotherapy.

In a new study, scientists have found that residential wood burning is a major contributor to winter air pollution across the United States. It further states that although only 2 % of U.S. homes rely on wood as their primary heating source, residential wood burning accounts for more than one-fifth of Americans’ wintertime exposure to outdoor fine particulate matter (PM2.5).

High blood pressure remained undetected in 59% of participants with hypertension in a large study in England. Half of those taking medication still had elevated readings, prompting calls for better detection and treatment.

Researchers have developed a microrobot which has the capacity to transport drugs to specific locations within the body. The microrobot has the potential to be used in hospitals in the near future.