German China
Cyphotilapia gibberosa is one of the particularly curious cichlids in Lake Tanganyika. (Source: University of Basel, Adrian Indermaur)
CRISPR-Cas9

Curiosity and Caution: How Behavioral Traits Shape Evolution

A study by the University of Basel, employing new genetic analysis methods, reveals how curiosity is genetically embedded in cichlids, and possibly linked to evolutionary and species diversification processes. This research not only deepens understanding of animal behavior but hints at genetic connections relevant to human psychological health.

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Tumors are known to disperse, or shed, their DNA into the environments surrounding them. (Source: free licensed)
Biosensor Leverages CRISPR

Researchers Engineer Bacteria that Can Detect Tumor DNA

Researchers from the University of California San Diego, in collaboration with Australian colleagues, have developed bacteria that can detect tumor DNA within a live organism. This breakthrough showed the potential of using the newly designed “Cellular Assay for Targeted CRISPR-discriminated Horizontal gene transfer” system to identify the presence of cancer in the colons of mice.

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Galleries

An up-close look at a mouse’s liver; the cells with dark centers were turned cancerous using a new gene-editing strategy devised by Semir Beyaz’s lab. (Source: Beyaz lab/Cold Spring Harbor Laboratory)
Cancer Research

CRISPR Reveals Multiple Personalities of Cancer Cells

Mutations in our genes can lead to severe problems, like colon or liver cancer. But cancer is very complex. Mutations in the same genes can lead to different subtypes of tumors in different people. Currently, there is no good way to produce such tumor subtypes for study. Now, scientists created a method to model certain liver cancer tumor subtypes using the gene-editing tool CRISPR-Cas9.

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Scientists from Gladstone and UCSF have shed light on exactly how neurons consume and metabolize glucose, which could have implications for understanding neurodegenerative diseases. Seen here are Ken Nakamura (left), Yoshi Sei (center), and Myriam Chaumeil (right). (Source: Michael Short/Gladstone Institutes)
Glucose Metabolization

Sugar Rush: Key Role of Glucose in Brain Activity Discovered

The human brain has a sweet tooth, burning through nearly one quarter of the body’s sugar energy, or glucose, each day. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have shed new light on exactly how neurons — the cells that send electrical signals through the brain — consume and metabolize glucose, as well as how these cells adapt to glucose shortages

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Shah’s team engineered living tumor cells using the gene editing tool Crispr-Cas9 and repurposed them to release tumor cell killing agent.  (Source: Pixabay)
Cell Therapy

Testing the Cancer Vaccine

Scientists at the Brigham and Women’s Hospital have tested a new cancer vaccine which kills as well as prevents brain cancer. The experts used a new cell therapy approach to eliminate established tumors and train the immune system to prevent cancer from recurring in the future.

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