Cooling Systems Reproducible Small Scale Reaction Chemistry at Low Temperatures
Asynt has published a case study describing how the Frosyn Cooling Station has enabled John Bower’s Group at the University of Liverpool, UK, to reproducibly conduct low temperature enantioselective catalytic reactions, over an extended period of time.
Isleham/UK — The Frosyn system, jointly developed by Asynt and temperature control specialists, Julabo UK, offers a versatile, stand-alone solution to low temperature synthetic chemistry without the drawbacks of traditional reaction cooling using dry ice / solvent baths.
Using a Pt100 sensor positioned in its insulated baseplate, the Frosyn provides precise, active temperature control down to -60 °C, eliminating temperature fluctuations over time. This approach to sample cooling results in excellent reproducibility and improved reaction control. Unlike dry ice cooling baths that require constant attention, the stable and controlled sub-ambient performance of the Frosyn means that unattended overnight reactions can be performed with complete confidence. Positioning of the Frosyn on top of a conventional magnetic stirrer enables efficient sample mixing during cooled experiments. Advanced thermal insulation, around the cooling probe and plate, not only improves performance, but keeps the apparatus ice-free and helps eliminate the possibility of operator cold burns during reactions.