MIT engineers have devised a double-sided adhesive that can be used to seal tissues together. This adhesive binds wet surfaces within seconds and could be used to heal wounds or implant medical devices.
Cambridge/USA — Inspired by a sticky substance that spiders use to catch their prey, MIT engineers have designed a double-sided tape that can rapidly seal tissues together. In tests in rats and pig tissues, the researchers showed that their new tape can tightly bind tissues such as the lungs and intestines within just five seconds. They hope that this tape could eventually be used in place of surgical sutures, which don’t work well in all tissues and can cause complications in some patients.
The double-sided tape can also be used to attach implantable medical devices to tissues, including the heart, the researchers showed. In addition, it works much faster than tissue glues, which usually take several minutes to bind tightly and can drip onto other parts of the body.
A Tight Seal
Forming a tight seal between tissues is considered to be very difficult because water on the surface of the tissues interferes with adhesion. Existing tissue glues diffuse adhesive molecules through the water between two tissue surfaces to bind them together, but this process can take several minutes or even longer.
The MIT team wanted to come up with something that would work much faster. Xuanhe Zhao is an associate professor of mechanical engineering and of civil and environmental engineering at MIT and the senior author of the study. His group had previously developed other novel adhesives, including a hydrogel superglue that provides tougher adhesion than the sticky materials that occur in nature, such as those that mussels and barnacles use to cling to ships and rocks.
To create a double-sided tape that could rapidly join two wet surfaces together, the team drew inspiration from the natural world — specifically, the sticky material that spiders use to capture their prey in wet conditions. This spider glue includes charged polysaccharides that can absorb water from the surface of an insect almost instantaneously, clearing off a small dry patch that the glue can adhere to.
To mimic this with an engineered adhesive, the researchers designed a material that first absorbs water from wet tissues and then rapidly binds two tissues together. For water absorption, they used polyacrylic acid, a very absorbent material that is used in diapers. As soon as the tape is applied, it sucks up water, allowing the polyacrylic acid to quickly form weak hydrogen bonds with both tissues.
These hydrogen bonds and other weak interactions temporarily hold the tape and tissues in place while chemical groups called NHS esters, which the researchers embedded in the polyacrylic acid, form much stronger bonds, called covalent bonds, with proteins in the tissue. This takes about five seconds.
To make their tape tough enough to last inside the body, the researchers incorporated either gelatin or chitosan (a hard polysaccharide found in insect shells). These polymers allow the adhesive to hold its shape for long periods of time. Depending on the application that the tape is being used for, the researchers can control how fast it breaks down inside the body by varying the ingredients that go into it. Gelatin tends to break down within a few days or weeks in the human body, while chitosan can last longer (a month or even up to a year). Combining two innovative concepts, the research team succeeded in adhering quickly and effectively to the wet and soft surface of a tissue, and in maintaining good adhesion and mechanical properties for several days without causing too much inflammatory response.
This type of adhesive could have a major impact on surgeons’ ability to seal incisions and heal wounds, Yuk says. To explore possible applications for the new double-sided tape, the researchers tested it in a few different types of pig tissue, including skin, small intestine, stomach, and liver. They also performed tests in pig lungs and trachea, showing that they could rapidly repair damage to those organs.
The tape also worked well to seal damage to the gastrointestinal tract, which could be very useful in preventing leakage that sometimes occurs following surgery. This leakage can cause sepsis and other potentially fatal complications.
Implanting medical devices within the body is another application the MIT team is exploring. Working with Roche’s lab, the researchers showed that the tape could be used to firmly attach a small polyurethane patch to the hearts of living rats, which are about the size of a thumbnail. Normally this kind of procedure is extremely complicated and requires an experienced surgeon to perform, but the research team was able to simply stick the patch on with their tape by pressing for a few seconds, and it stayed in place for several days. In addition to the polyurethane heart patch, the researchers found that the tape could successfully attach materials such as silicone rubber, titanium, and hydrogels to tissues.
The researchers are now working with doctors to identify additional applications for this kind of adhesive and to perform more tests in animal models.