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UK: Analytical Technologies Detection of Glyphosate and Other Pesticides in a Single Run

| Editor: Alexander Stark

Sciex has developed the first non-derivatised method using LC-MS/MS for quick and simple detection and quantitation of glyphosate and other polar pesticides in food, feed and water commodities.

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Glyphosate use has regularly been questioned due to its potentially hazardous nature to humans and toxicity to aquatic life.
Glyphosate use has regularly been questioned due to its potentially hazardous nature to humans and toxicity to aquatic life.
(Source: CC0 Pixabay)

Warrington/UK — Glyphosate is a broad-spectrum systemic herbicide that is used by farmers worldwide. Its use has regularly been questioned due to its potentially hazardous nature to humans and toxicity to aquatic life. However, the regulatory bodies have differing opinions on these issues and its use in farming is still authorised.

Previous analytical strategies, especially for LC-MS/MS analysis, have required laborious and often time-consuming derivatisation of glyphosate and its metabolites to allow the polar nature of the compounds to be identified more easily under reverse-phase LC-MS conditions. To simplify the sample preparation and thus the overall method, Sciex partnered with the Rotterdam-based contract testing laboratory, Nofalab, to develop a non-derivatised method.