These Complexes Are Promising Ligands for Nuclear Medicine

Czech Republic: Radioisotope Carriers These Complexes Are Promising Ligands for Nuclear Medicine

18.03.2021Editor: MA Alexander Stark

Scientists at Charles University, Prague, synthesized cross-bridged cyclam derivatives bearing two phosphonate, bis(phosphinate), or phosphinate pendant arms and studied them with respect to their application as copper radioisotope carriers in nuclear medicine. Their studies show that the materials are highly promising ligands for nuclear medicine.

Related Vendor

Charles University in Prague

A new discovery shows that phosphonate and bis(phosphinate) derivatives are promising ligands for nuclear medicine.
(Source: Public Domain / Pixabay )

Prague/Czech Republic — In a recent study, Czech scientists examined the properties of cross-bridged cyclam with phosphonate and phosphinate pendant arms as radioisotope carriers used in nuclear medicine. The ligands showed high macrocycle basicity and high copper complex stability. The complexation and dissociation kinetics of the copper complexes were studied by ultraviolet–visible spectroscopy. Phosphonate and bis(phosphinate) copper complexes form very quickly, reaching quantitative formation in few seconds. Conversely, the formation of the phosphinate complex is much slower due to the low stability of the reaction intermediate.

All studied complexes are highly kinetically inert. The high thermodynamic stability, fast formation, and extreme kinetic inertness of the complexes indicate that phosphonate and bis(phosphinate) derivatives are promising ligands for nuclear medicine.

Nuclear medicine is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear medicine imaging, in a sense, is “radiology done inside out” or “endoradiology” because it records radiation emitting from within the body rather than radiation that is generated by external sources like X-rays. In addition, nuclear medicine scans differ from radiology, as the emphasis is not on imaging anatomy, but on the function.

References: Cross-Bridged Cyclam with Phosphonate and Phosphinate Pendant Arms: Chelators for Copper Radioisotopes with Fast Complexation

Subscribe to the newsletter now

Don't Miss out on Our Best Content

Business E-mail

Please enter a valid mailadress.

By clicking on „Subscribe to Newsletter“ I agree to the processing and use of my data according to the consent form (please expand for details) and accept the Terms of Use. For more information, please see our Privacy Policy.

Stand vom 23.03.2021

Naturally, we always handle your personal data responsibly. Any personal data we receive from you is processed in accordance with applicable data protection legislation. For detailed information please see our privacy policy.

Consent to the use of data for promotional purposes

I hereby consent to Vogel Communications Group GmbH & Co. KG, Max-Planckstr. 7-9, 97082 Würzburg including any affiliated companies according to §§ 15 et seq. AktG (hereafter: Vogel Communications Group) using my e-mail address to send editorial newsletters. A list of all affiliated companies can be found here

Newsletter content may include all products and services of any companies mentioned above, including for example specialist journals and books, events and fairs as well as event-related products and services, print and digital media offers and services such as additional (editorial) newsletters, raffles, lead campaigns, market research both online and offline, specialist webportals and e-learning offers. In case my personal telephone number has also been collected, it may be used for offers of aforementioned products, for services of the companies mentioned above, and market research purposes.

In case I access protected data on Internet portals of Vogel Communications Group including any affiliated companies according to §§ 15 et seq. AktG, I need to provide further data in order to register for the access to such content. In return for this free access to editorial content, my data may be used in accordance with this consent for the purposes stated here.

Right of revocation

I understand that I can revoke my consent at will. My revocation does not change the lawfulness of data processing that was conducted based on my consent leading up to my revocation. One option to declare my revocation is to use the contact form found at https://support.vogel.de. In case I no longer wish to receive certain newsletters, I have subscribed to, I can also click on the unsubscribe link included at the end of a newsletter. Further information regarding my right of revocation and the implementation of it as well as the consequences of my revocation can be found in the data protection declaration, section editorial newsletter.

(ID:47299248)