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An IDH-mutant human glioma tumor, showing clusters of CD8+ T cells in green, and a gradient of purple to pink representing low to high D-2HG concentrations. CD8+ T cells were more abundant in areas with less D-2HG, and less abundant in regions with more D-2HG, suggesting that D-2HG has an effect on the immune cells. (Source: Gregory Baker, HMS)
Cancer Cells

How Certain Cancers Neutralize T Cells

New findings published by a team led by researchers at Harvard Medical School offer insight into how certain cancers disarm the immune system so that tumor cells can grow and divide. The findings highlight the role of the immune system in certain types of cancers, and could inform the development of better treatments.

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Galleries

Scientists from Gladstone and UCSF have shed light on exactly how neurons consume and metabolize glucose, which could have implications for understanding neurodegenerative diseases. Seen here are Ken Nakamura (left), Yoshi Sei (center), and Myriam Chaumeil (right). (Source: Michael Short/Gladstone Institutes)
Glucose Metabolization

Sugar Rush: Key Role of Glucose in Brain Activity Discovered

The human brain has a sweet tooth, burning through nearly one quarter of the body’s sugar energy, or glucose, each day. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have shed new light on exactly how neurons — the cells that send electrical signals through the brain — consume and metabolize glucose, as well as how these cells adapt to glucose shortages

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