Heart Wellness You Might Be at Risk of Cardiovascular Disease Even if You Have Stable Blood Pressure

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A new study has revealed that the bodies of patients dealing with hypertension adapts to the condition by developing a set of ‘new senses’.

Bristol/UK – Researchers studying how hypertension increases the risk of heart attacks and strokes have discovered a remarkable way in which the body adapts to hypertension by developing a set of “new senses”.

The study, conducted by experts in Translational Health Research at the University of Bristol and published on 26 August in ‘Circulation Research’, could have important implications for developing new therapies to counter the elevated risk of cardiovascular events among people diagnosed with high blood pressure.

Prior to this study, it remained unknown why people on antihypertensive medications were able to successfully reduce their blood pressure and yet remained at high risk of a major cardiovascular event even where they adhered to medication protocols and observed a healthy lifestyle.

Researchers from Bristol Medical School surmised from these studies – one drawing on a large European populace, the other focused on Korea – that hypertension in these cases may have been merely a symptom rather than the underlying cause of a life-threatening heart attack or stroke.

The answer, as discovered by this latest study, lies in the brain, specifically abnormal activity in the sympathetic nervous system, which is responsible for the body’s flight or fight response to stress.

In healthy individuals, this system oversees a variety of functions including elevating the body’s blood pressure and heart rate as a normal response to exercise. However, according to earlier research in a separate study, hypertensive patients’ sympathetic activity does not decrease at rest and is on average 1.5X greater compared to those without hypertension.

In order to pinpoint why that is the case, Bristol’s Professor David Murphy worked with Professor Julian Paton from the University of Auckland turned to the mechanism controlling sympathetic activity in an experimental model of hypertension.

“One such mechanism is the arterial chemoreflex which continuously monitors our blood for oxygen and sends a powerful signal to the brain to stimulate breathing and make our heart pound, say when we dive or start running out of breath under water,” explains Dr Audrys Pauza, who contributed to the study as part of his PhD and is a lead author on the paper.

“We found that instead of acting as a quiescent monitor of blood oxygen as it ordinarily does, that very same reflex becomes continuously active in hypertension, leading to chronically elevated sympathetic nerve activity. We found that one of the reasons for this is that the arterial chemoreflex develops new senses to respond to hormone signals circulating in the bloodstream as a result of hypertension.”

The study is the first to describe how the arterial chemoreflex is activated by the melanocortin system, which is traditionally associated with skin pigmentation and the body’s response to stress.

Crucially, the Bristol study adds to the body of work showing that when this reflex is inhibited in hypertensive state, both blood pressure and sympathetic activity is reduced. This work opens an unprecedented opportunity to finally temper the overactive sympathetic drive that fuels cardiovascular risk in hypertension.

Audrys now aims to translate these pre-clinical findings to patients living with hypertension, and to ascertain exactly why the arterial chemoreflex becomes sensitive to melanocortin hormones.

“Initiated during my time in Bristol, this study has been a major catalyst for my career and I’m delighted to see the results finally published,” said Audrys, who undertook part of the research during his BHF-funded 4-year PhD programme at Bristol. He has since relocated to New Zealand, where he continues his research with support from the National Heart Foundation of New Zealand, the Health Research Council, and the Partridge Family Foundation.

Paper: “Melanocortin System Activates Carotid Body Arterial Chemoreceptors in Hypertension”, by Audrys Pauza et al, published in ‘Circulation Research’, the flagship journal of the American Heart Association.

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