German China
The two conventional modes of a scanning electron microscope (SEM and STEM; left and center) were unable to generate images of the biomolecules. However, holographic imaging mode (right), can be used to image biomolecules, such as the tobacco mosaic virus shown. (Source:Modified from M Cheung, H Adaniya, C Cassidy, M Yamashita, T Shintake)
Innovation

Scientists Pave the Way to more Affordable and Accessible Cryo-EM

Visualising the structure of viruses, proteins and other small biomolecules can help scientists gain deeper insights into how these molecules function, potentially leading to new treatments for diseases. In recent years, a powerful technology called cryogenic electron microscopy (cryo-EM), where flash-frozen samples are embedded in glass-like ice and probed by an electron beam, has revolutionised biomolecule imaging. However, the microscopes that the technique relies upon are prohibitively expensive and complicated to use, making them inaccessible to many researchers.

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Biomolecules are responsible for numerous functions in the body. Deciphering their structure is not always easy. (University Duisburg Essen/Schug)
Artificial Intelligence

How Swarm Learning Can Decode Biomolecules

They are often referred to as the “building blocks of life”: Biomolecules. To understand and use their function in the body, one must know their structure. A time-consuming and sometimes imprecise matter. This is where the new method comes in, which was developed at the UDE with other German research centres — with the help of artificial intelligence. The researchers have now published their results in Nature Machine Intelligence.

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Waters expands its existing collaboration with the Bioprocessing Technology Institute, A*Star into new areas meant to accelerate bioprocessing and bioinformatics research. (Public Domain)
USA: Optimization of Analytical Workflow

Research Collaboration Between Waters and BTI to Accelerate Biologics Production

Waters Corporation announced an expansion of its joint work with the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*Star). Among their new collaborative projects, the partners have started work on applying analytics that can help ensure overall safety, accuracy, and speed of biologics manufacturing.

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Researchers from the University of Tsukuba identified a novel mechanism that determines how mating affects the behavior of germline stem cells. (Yuto Yoshinari)
Japan: Stem Cell Research

The Molecular Stimulus of Mating

While it is known that stem cells have the ability to develop into all tissues in a precisely regulated process, the way environmental cues affect stem cell behavior has remained poorly understood. In a new study, researchers from the University of Tsukuba discovered that certain neurons regulate the behavior of germline stem cells (GSCs) in response to environmental cues, such as mating.

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Fig.1: There are several therapeutic Antibodies currently in late stages of clinical trials (representative picture). (©psdesign1 - stock.adobe.com)
Size Exclusion Chromatography and UHPLC

Chromatography: Size Matters

Quick and straightforward, aqueous size exclusion chromatography (SEC) has become a mainstay for the analysis of protein aggregates in the biopharmaceutical industry. Coupling SEC with advanced detection, such as mass spectrometry, light scattering or surface plasmon resonance, makes it a versatile tool for numerous applications beyond aggregate analysis.

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