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Preperative SFC Chromatography Purification of Pharmaceutical Products

| Editor: Marc Platthaus

Shimadzu has released the Nexera UC Prep, a Preparative Supercritical Fluid Chromatography system. It is part of Shimadzu’s Nexera UC platform and can be configured according to user specifications, for optimum performance of the desired purification function.

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New Nexera UC Prep, Preparative Supercritical Fluid Chromatography System
New Nexera UC Prep, Preparative Supercritical Fluid Chromatography System
(Source: Shimadzu Europe)

Shimadzu has released the Nexera UC Prep, a Preparative Supercritical Fluid Chromatography System. This next-generation prep SFC system provides the pharmaceutical industry with reliable high-performance semi-prep purification. The Semi-Prep SFC is the fruit of a collaborative effort by pharma and private industry, serving as the model for future product design with impact. The company has worked closely together with the Enabling Technologies Consortium (ETC). This group of pharmaceutical and biotechnology companies has allied to speed up the process of creating technologies necessary for their projects. They work with third parties to discuss ideas, share information and collaborate on the development of new enabling technologies.

The Nexera UC Prep resolves a number of issues in preparative tasks, reducing labor and improving efficiency while fitting into pre-existing workflows, as the company pointed out. It provides flexible system configurations in a compact design, requiring low installation space and enabling maximum use of lab resources.

The Nexera UC Prep is part of Shimadzu’s Nexera UC platform, which accommodates a wide variety of analyses and purifications. A Nexera UC Prep system can be configured according to user specifications for optimum performance of the desired purification function, including chiral or achiral purifications, single injections, stacked injections and fraction collections from several microliters to liters.

This complete SFC solution reduces the need for costly and hazardous solvents used in normal phase prep LC, while shortening purification run time and dry down time. Innovative technologies include a flexible format, combination injector/fraction collector, and CO2 pump with integrated chiller requiring less lab space, thereby enabling benchtop use. The novel and patented “LotusStream” gas-liquid separator technology ensures higher recovery and lower carryover than earlier prep SFC systems. Its elegant design reduces the total size of the recovery system and allows for easy rinsing compared to earlier cyclone-style or centrifugal type gas-liquid separating systems. The newly developed, easy-to-use “Prep Solution” software streamlines operations. It simplifies configuration of parameter settings and greatly increases efficiency of the preparative workflow.

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