Sustainable Solution New Centrifuge Technology for Large-Scale Cell Culture Harvesting

Thermo Fisher Scientific has recently introduced its Dynaspin Single-Use Centrifuge system. Offering a single-use solution for large-scale cell culture harvesting, the firm’s innovation is also capable of reducing the usage of traditional depth filtration to develop a more cost-efficient solution in a shorter span of time.

Thermo Fisher Scientific has recently unveiled the Thermo Scientific Dynaspin Single-Use Centrifuge system at the Bioprocess International annual conference in Boston, MA, USA. The system is specifically designed to provide an optimal single-use solution for large-scale cell culture harvesting. The Dynaspin system improves and streamlines harvesting for cell culture separation in single-use bioprocesses by reducing the number of depth filtration cartridges required to complete the harvest process. The solution delivers equivalent or improved product yield compared to traditional harvest systems while enabling operational efficiency, cost savings and sustainable practices in the production of biologics, states the company.

The system helps reduce overall production costs while allowing biologic manufacturers to support their sustainability goals. By reducing the number of filters required for harvesting, this product offers upwards of six-fold reduction in material requirements, eliminating 70 % of waste compared to traditional harvest systems, adds the firm.

The company developed the Dynaspin system with an eye on efficiently harvesting biologics at a large-scale, such as from its 5,000-liter Thermo Scientific Dynadrive Bioreactor. It was critical that the solution also consider the environment while outperforming traditional harvest solutions and delivering consistent product yields to the firm’s customers. The technology meets these objectives and will help its customers provide greater accessibility of therapeutics and vaccines globally.

In addition to the optimized design and smaller equipment footprint, the system incorporates the well-documented advantages of single-use products including scalability, rapid change over, reduced downtime and lower risk of contamination to the workflow.

According to the company, the ergonomic design of the system provides ease of access for system operation and maintenance, including loading and unloading the single-use rotor and line set assembly. Dynaspin brings automation technology which was not previously available in single-use solutions for harvesting. It provides configurable user access, audit trail and batch reporting, enabling users to meet their digital requirements.

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