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UK: Biomedicine Collagen from Jellyfish Set to Revolutionize Tissue Engineering

Editor: Alexander Stark

Jellagen has developed a manufacturing process that allows laboratory technicians to scale up the production of collagen from jellyfish. The resulting product is a new jellyfish collagen hydrogel suitable for 3D cell culture and tissue engineering.

Jellagen launches their first purified jellyfish collagen hydrogel: Jellagel.
Jellagen launches their first purified jellyfish collagen hydrogel: Jellagel.
(Source: CC0 / Pixabay )

Cardiff/UK — Jellyfish collagen constitutes an ancient chemical template of all collagens. The new product launched by Jellagen is a versatile hydrogel product based on collagen from jellyfish. Unlike mammalian collagens, Jellagel is free from carry-over contaminants (e.g. proteins, polysaccharides, disease vectors). It also contains lower non-specific miRNA than mammalian collagens, reducing off-target effects. When compared with synthetic materials, many of which are based on β-structured fibrous materials, jellyfish collagen is bioresorbable and non-toxic to cells, from stem to lineage cells.

In a recent collaborative study with the National Physical Laboratory (NPL) as part of Innovate UK’s Analysis for Innovators (A4I) programme, the company sought to develop a robust protocol for the culturing of cell lines in three dimensions. The study performed an in-depth analysis of jellyfish collagen materials and showed that these are able to effectively encapsulate cells, while retaining their viability. According to Nilofar Faruqui, a research scientist from the National Physical Laboratory who led the project, 3D tissue scaffolds such as hydrogels hold great promise for biomedicine including applications in cell therapies and regenerative medicine.