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USA: Magnetic Resonance Technology Bruker Introduces Novel NMR and Analysis Solutions

Editor: Alexander Stark

Bruker announced new software and hardware addressing the need for enhanced workflow solutions for NMR spectroscopy research and analysis.

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The new bio Top module performs most biomolecular tasks in full automation
The new bio Top module performs most biomolecular tasks in full automation
(Source: Bruker)

Asilomar/USA — Top Spin 4 is the next generation NMR software for spectrometer control and data analysis, designed for the newly introduced Avance Neo platform. This new NMR software features a new user interface and supports multiple receivers and other Avance Neo capabilities. Existing Avance III HD customers will also benefit from a new Top Spin 3.5 version, as the company continues enhancements and support for the Avance III HD platform.

Designed to simplify and accelerate the setup of biomolecular NMR experiments, the new bio Top module performs most biomolecular tasks in full automation. Only minimal user interaction is required for most experiments. The process starts after inserting the sample, taking care of shimming, locking and tuning if necessary. From experiment selections to final processed spectra, including optimization of commonly used parameters, bio Top can be customized to accommodate much of the workflow in biomolecular NMR laboratories.

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The new Top Solids module is an intuitive, workflow-based software for solid-state NMR. Top Solids is designed to give easy access to the delicate setup of probe hardware and complex solid-state NMR experiments, e.g. from structural biology on membrane proteins, to pharmaceutical compounds, to catalysis, battery research, polymer or material science work.

Biotech and Pharma Solutions

NMR Fragment-based Screening (FBS) in the pharmaceutical industry has become a widely applied method for the discovery and optimization of lead molecules in targeted screening campaigns. The new FBS workflow solution is built into Top Spin and streamlines FBS data handling and analysis, thus providing an easier way to screen compounds to find potential new drugs.

For NMR detection, the company introduced the new i-Probe platform. This novel NMR probe architecture allows not only for an increase in signal to noise, and faster and more accurate rf tuning, but also provides a more flexible design that allows easier customization of NMR probes for dedicated applications. The first probes introduced on this platform include the industry-leading Smart Probe i-Probes, available now from 400-600 MHz, offering up to 10 % increase in sensitivity.

The Insight MR portfolio of applications for monitoring chemical and biological processes is expanding further, in order to increase understanding of reaction mechanisms, chemical processes as well as cell metabolism. Insight Xpress now enhances the NMR monitoring of fast reactions and rapid, automated, screening of reactions conditions. For studies on living cells, Insight Cell now monitors living cells to study their biological activity through direct NMR measurements of variations in metabolite concentration.

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