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Sweden: Calcium Ions

Why Loud Sounds Impair Hearing

| Editor: Alexander Stark

Pierre Hakizimana is one of the researchers behind the new study on hearing.
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Pierre Hakizimana is one of the researchers behind the new study on hearing. (Source: Thor Balkhed)

Most people have experienced that their hearing is impaired and the ear feels numb after listening to loud sounds. After a while hearing returns to normal. Swedish scientists have discovered that a tiny structure in the cochlea known as the tectorial membrane plays an important role in this process, by acting as a storage depot for calcium ions

Linköping/Sweden — Calcium ions, which are calcium atoms with a positive charge, play a key role in the processes that make hearing possible. The conversion of sound waves to nerve impulses takes place in the inner ear, also known as the cochlea, which looks like the spiral shell that some snails have. The cochlea contains many sensory cells, which detect sounds and generate signals that are passed on to the brain.

Previous research has shown that the fluid that surrounds the sensory cells in the cochlea has a low concentration of calcium ions. There were, however, questions surrounding this, because sensory cells that are placed in fluids with the natural level of calcium no longer work normally. The scientists at Liu (Linköping University) have investigated the calcium ion concentration in the inner ear of guinea pigs, which is very similar to the human ear. By fluorescently labelling the calcium ions, the researchers discovered that a membrane that lies on top of the sensory cells, the tectorial membrane, has a much higher concentration of calcium ions than the surrounding fluid. The membrane seems to function as a store, such that the sensory cells are surrounded by higher levels of calcium ions than previously believed.

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When the scientists added a substance that mops up calcium ions, the sensory cells ceased to function. In the next step, they exposed the inner ear to noise levels that correspond to those experienced at rock concerts, which had the same effect. When they expose isolated inner ears to loud noise in the lab, the level of calcium in the tectorial membrane falls, and the sensory cells cease to function. After a while, the calcium ion concentration returns to its previous level, and the sensory cells start to function again.

Until now, scientists have thought that the tiny membrane has a mainly mechanical function, but the discovery made by the LiU researchers suggests that the tectorial membrane may play an important role in regulating hearing by storing calcium.

The research group is now planning to investigate whether the same mechanism is important in age-related hearing impairment. The research has been financed by, among other contributors, the Swedish Research Council, the Torsten Söderberg Foundation, the Tysta Skolan Foundation and AFA Försäkrings AB.

Reference: The article: “Control of hearing sensitivity by tectorial membrane calcium”, Clark Elliott Strimbu, Sonal Prasad, Pierre Hakizimana and Anders Fridberger, (2019), PNAS, published online March 5, 2019, doi: 10.1073/pnas.1805223116

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