USA: Autoimmunity Simple Blood Test Predicts Foods That Cause Autoimmunity
Scientists at Yale reported a blood test for identifying patient specific reactions to foods and chemicals, may help doctors and patients unveil a hidden cause of autoimmune and other inflammation related conditions.
Deerfield Beach/USA — The report was published in the journal, Nutrition & Metabolism, in a paper entitled, A Leukocyte Activation Test Identifies Food Items Which Induce Release of DNA by Innate Immune Peripheral Blood Leukocytes.
The scientists studied various immunological phenomena associated with cellular reactions measured by the Alcat Test, wherein a patient’s blood is exposed to specific food extracts and a sensitive instrument records innate immune cell responses. The Yale researchers, led by the late Dr. Ather Ali, ND, MPH, and Wajahat Mehal, M.D., Ph.D., had previously reported that diets determined by Alcat testing significantly reduce symptoms of irritable bowel syndrome (IBS).
The investigators wondered if this improvement in IBS symptoms is linked to release of DNA from activated white blood cells. Numerous studies from various institutions have found that DNA released from activated immune cells trigger inflammatory responses.
The Yale team did find that positive Alcat reactions are associated with a greater release of DNA than are Alcat Test, “non-reactive” foods. They also identified the immunological pathway most involved, Protein Kinase C (PKC) as well as the primary cell type initiating the reactivity; the eosinophil. Activation of this cell type, and this pathway, are often associated with aberrant immune responses. Epigenetic studies show that foods modify gene expression and, quite possibly, the immune system can recognize foods that do so negatively.
The findings suggest that dietary triggers may play a role in wide ranging and disparate inflammation associated disorders; such as, multiple sclerosis, gastro enteropathies, asthma, arthritis, metabolic syndrome (obesity, cardiovascular disease and Type 2 diabetes) inflammation of the liver and other target organs, dementia, eczema, psoriasis, and eosinophilic esophagitis, to name a few.
More about the Alca Test