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Viruses Encoded Biosensors Real-time Biochemistry of Living Cells and Whole Organisms

Editor: Doris Popp

The new GCaMP calcium indicators (jGCaMP7b, jGCaMP7c, jGCaMP7f, jGCaMP7s) enlarge the portfolio of ready-to-use adeno-associated virus (AAV) biosensor products of Amsbio.

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Amsbio AAV Biosensors
Amsbio AAV Biosensors
(Source: AMS Biotechnology)

These viruses encoded biosensors are supplied ready for use for neural activity studies in vivo. AAV biosensors provide a snapshot of intracellular interactions, specifically active brain circuitry. Using fluorescent protein-based AAV biosensors allows permanent marking of active cells over short time scales, providing a window into the real-time biochemistry of living cells and whole organisms. GCaMP is a genetically encoded calcium indicator (GECI) generated from a fusion of the green fluorescent protein (GFP), calmodulin, and M13, a peptide sequence from myosin light chain kinase. Upon binding of GECI to Ca2+ there is an induction of a change in fluorescence signal. It is this change in signal that allows for measurement of the action potentials, and other receptor activation events, that trigger Ca2+ fluxes.

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