German China

Viruses Encoded Biosensors Real-time Biochemistry of Living Cells and Whole Organisms

Editor: Doris Popp

The new GCaMP calcium indicators (jGCaMP7b, jGCaMP7c, jGCaMP7f, jGCaMP7s) enlarge the portfolio of ready-to-use adeno-associated virus (AAV) biosensor products of Amsbio.

Related Vendors

Amsbio AAV Biosensors
Amsbio AAV Biosensors
(Source: AMS Biotechnology)

These viruses encoded biosensors are supplied ready for use for neural activity studies in vivo. AAV biosensors provide a snapshot of intracellular interactions, specifically active brain circuitry. Using fluorescent protein-based AAV biosensors allows permanent marking of active cells over short time scales, providing a window into the real-time biochemistry of living cells and whole organisms. GCaMP is a genetically encoded calcium indicator (GECI) generated from a fusion of the green fluorescent protein (GFP), calmodulin, and M13, a peptide sequence from myosin light chain kinase. Upon binding of GECI to Ca2+ there is an induction of a change in fluorescence signal. It is this change in signal that allows for measurement of the action potentials, and other receptor activation events, that trigger Ca2+ fluxes.

Subscribe to the newsletter now

Don't Miss out on Our Best Content

By clicking on „Subscribe to Newsletter“ I agree to the processing and use of my data according to the consent form (please expand for details) and accept the Terms of Use. For more information, please see our Privacy Policy.

Unfold for details of your consent

(ID:45805558)