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Fluorescence Microscope Observing Live Samples Over Extended Periods

Editor: Doris Popp

The new Fluorescence Microscope Zeiss Lightsheet 7 is designed to observe living samples over extended periods of time, or to image large optically cleared specimens.

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Zeiss Lightsheet 7
Zeiss Lightsheet 7
(Source: Zeiss)

Specimens with a size up to 2 cm, with a refractive index between 1.33 and 1.58, and in almost any clearing solution can be accommodated. The stable turnkey system allows acquisition of overview images as well as of data with subcellular resolution. Researchers can now perform fast and gentle LSFM imaging of optically cleared organoids, spheroids, organs, brains, or other specimens. Zeiss Lightsheet 7 features the high-quantum efficiency of pco.edge sCMOS detectors to enable observations of the fastest processes at the lowest illumination light levels. Scientists are able to obtain a real-life view of large samples without the adverse effects of excitation light on their biology. For vertically oriented specimens and highest frame rates, the CMOS detector Zeiss Axiocam 702 can be used. A special sample chamber provides heating, cooling, and CO2. Adding Multiview and triggering options to control external devices makes it possible to observe live processes in an almost unlimited range of organisms.