Avolition Scientists Identify a Brain “Brake” That Blocks Motivation

A new neuroscience study reveals a specific brain circuit that suppresses the urge to act when tasks are stressful or unpleasant, offering fresh insight into why getting started can feel so difficult—and what this means for mental health.

Most of us know the feeling: maybe it is making a difficult phone call, starting a report you fear will be criticized, or preparing a presentation that’s stressful just to think about. You understand what needs to be done, yet taking that very first step feels surprisingly hard. When this difficulty becomes severe, it is known medically as avolition. People with avolition are not lazy or unaware: they know what they need to do, but their brain seems unable to push the “go” button. Avolition is commonly seen in conditions such as depression, schizophrenia, and Parkinson's disease, and it seriously disrupts a person’s ability to manage daily life and maintain social functions.

Research in neuroscience and psychology has suggested that before we act, the brain weighs how much effort a task may cost. If the cost feels too high, motivation drops. But until now, it has been unclear how the brain turns this judgment into a decision not to act. To explore this question, a research team at WPI-Ashbi applied an advanced genetic technique called chemogenetics to highly intelligent macaque monkeys, allowing them to adjust communication temporarily and precisely between specific brain regions and identify a circuit that acts like a brake on motivation.

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Reward Versus Punishment: When Motivation Stalls

The monkeys were trained to perform two types of tasks. In one, completing the task earned a water reward. In the other, the reward came with an added downside: an unpleasant air puff to the face. Before each trial, the monkeys saw a cue and could freely decide whether to start or not. The researchers focused not on which option the monkeys chose, but on something more fundamental: did they take the first step at all? As expected, when the task involved only a reward, the monkeys usually got started without hesitation. But when the task involved an unpleasant air puff, they often held back, even though a reward was still available.

The researchers then temporarily weakened a specific brain connection linking two regions involved in motivation: the ventral striatum (VS) and the ventral pallidum (VP). In the reward-only task, suppressing this pathway had little effect on monkey behavior, and the monkeys initiated the task normally. In contrast, in tasks involving an unpleasant air puff, the mental brake to starting had eased: the monkeys became much more willing to start. Importantly, the monkeys' ability to judge rewards and punishments did not change. What changed was the step between knowing and doing.

The researchers took a closer look at what was actually happening in these brain regions during this process. Neural activity in the VS increased during the stressful task, suggesting it helps the brain register when a situation feels stressful. In contrast, activity in the VP gradually fell as the monkeys became less willing to start the task, showing that these two regions play different roles. Together, these findings show that the VS to VP pathway functions as a “motivation brake” that suppresses the internal “go” button, particularly when facing stressful or unpleasant tasks.

What the Findings Mean for Mental Health

This discovery of the VS–VP “motivation brake” may shed light on conditions such as depression and schizophrenia, where severe loss of motivation is common. In the future, interventions such as deep brain stimulation, non-invasive brain stimulation, or new drug strategies might aim to fine-tune this brake when it becomes too tight. But this “brake” exists for a reason. While an overly tight brake can lead to avolition, a brake that is too loose could make it harder to stop, even in excessively stressful situations, potentially leading to burnout. In other words, the VS–VP circuit may help keep motivation within a healthy range. “Over weakening the motivation brake could lead to dangerous behavior or excessive risk-taking,” said Ken-ichi Amemori, lead author of the study. “Careful validation and ethical discussion will be necessary to determine how and when such interventions should be used.”

In modern society, especially at a time when burnout is at an all-time high, these findings invite us to rethink what “motivation” really means. The brain can actively dampen the drive to act when tasks are unpleasant or stressful, so getting started is not simply about willpower. Rather than trying to forcibly boost motivation, the focus should shift toward how society can better support people in coping with stress. This is a question that warrants broader societal dialogue.

Original Article: Motivation under aversive conditions is regulated by a striatopallidal pathway in primates; Current Biology; DOI:10.1016/j.cub.2025.12.035

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