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HPLC Liquid Chromatography: Software Package Drastically Reduces Development Time

Editor: MA Alexander Stark

In a collaboration with Chromsword, Thermo Fisher Scientific have launched an automated high performance liquid chromatography (HPLC) and ultra-high performance liquid chromatography (UHPLC) method development system that enables chromatographers to deliver robust and validated methods in less time and with higher confidence.

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(Source: Thermo Fisher Scientific)

Germering/Germany — The new Thermo Scientific Vanquish Method Development HPLC and UHPLC system provides an integrated, network-deployable solution for automated method development and validation for diode-array, charged aerosol and mass spectrometric detection. Built for ease-of-use and speed, the system strategically combines the Vanquish HPLC and UHPLC systems and the Thermo Scientific Chromeleon Chromatography Data System (CDS) with Chromsword Auto and Chromsword Auto Robust software. It leverages artificial intelligence to minimize manual interaction and enables method creation for complete compound detection with no prior sample knowledge required. Enhanced confidence is assured through multiple detection capabilities, and the integrated Chromeleon Data Vault further reinforces data integrity and compliance.

In addition to speed and ease-of-use, the system offers high method flexibility to pharmaceutical, biopharmaceutical, chemical and food testing laboratories, featuring automated column switching and universal analyte detection, with mass spectrometry-based peak tracking capabilities delivering more reliable results. Using Chromeleon CDS with Chromsword Auto Chromeleon Connect and Chromsword Auto Robust Chromeleon Connect enables chromatographers to automate method development tasks, including method scouting, impurity profiling, fine optimization and method validation.