German China

Germany: Nutritional Science

Lifestyle Diseases Started 12.5 Million Years Ago

| Editor: Alexander Stark

Wild berries were a sweet temptation for our ancestors. (sample image)
Wild berries were a sweet temptation for our ancestors. (sample image) (Source: Pixabay / CC0)

A team of scientists found that the fruits likely consumed by the earliest representative of African apes and human in early winter had a high sugar and especially fructose content. This in turn led to the formation of body fat due to the lack of uricase in the metabolism.

Tübingen/Germany — Many of today’s lifestyle diseases may have their origin in a genetic mutation linked with high sugar intake and the storage of fat reserves, which first occurred in our ancestors many millions of years ago. Diabetes, high blood pressure, obesity and gout are diseases which according to the World Health Organization not only claim millions of human lives each year — they also occur in our nearest relatives, the orangutan, gorilla and chimpanzee. For about ten years researchers have suspected that the human predisposition to what we call “lifestyle diseases” may be due to our common evolutionary history. Unlike other primates, we, gorillas, orangutans and chimps lack the enzyme uricase in our metabolism. This leads to higher levels of uric acid in the blood, and sugars are transformed into body fat. Fructose (unlike glucose) increases this fat storage effect. Under the uricase theory, the genetic mutation leading to its loss must have occurred in our last common ancestor with chimps, gorillas and orangutans — 15 million years ago in what is now Europe.

Tübingen and Dresden researchers have now come up with paleontological evidence supporting this theory. Their team includes Professor Madelaine Böhme and Jochen Fuss of the University of Tübingen and the Senckenberg Centre for Human Evolution and Palaeoenvironment, and Gregor Uhlig of the Helmholtz Center Dresden-Rossendorf. The team found advanced tooth decay in the 12.5 million year old teeth of Dryopithecus carinthiacus, the earliest representative of African apes and humans. The teeth were found in Carinthia, Austria, in 1953.

The rise of tooth decay has always been placed in the context of early agriculture — the Neolithic revolution — some ten thousand years ago. We have been eating more cooked starches since then. A comprehensive comparative study of the state of the teeth of 365 wild chimpanzees in Liberia showed that only 0.17 % of them had signs of tooth decay. The tooth decay observed in chimpanzees is also much less pronounced than in the fossil primate.

Sweet Tooth

But unlike the tooth rot often found in early farmers, the decay in the Dryopithecus carinthiacus teeth was due to high levels of sugar consumption. To prove this, the researchers analyzed the fossil pollen from trees, bushes and vines present in the layers of the site in Carinthia where the 12.5 million year old jawbone was found. There they found at least nine species with high-sugar fruits, including grapes, mulberries, strawberry trees, chestnuts, oleaster, and types of wild cherry and plum. The scientists also found 46 melliferous plants — so honey could have been an additional source of sugar. According to the study, sugar was present for nine to ten months of the year, from March to December, in the Miocene landscape of what is now Carinthia. While today’s primates can eat young leaves if no fruit is available, the European primates did not have that emergency option. Madelaine Böhme, who headed the study, explains that because of the low light intensity, or the short hours of daylight in January and February, and despite nearly tropical temperatures in the northern mid-latitudes, there was no new leaf growth in late winter. To survive this starvation period, our ancestors had to put on reserves of fat, adds Chemist Gregor Uhlig.

Researchers Turn Unpleasant Soy Pulp into Healthy Probiotic Drink

Singapore: Food Science

Researchers Turn Unpleasant Soy Pulp into Healthy Probiotic Drink

08/29/2018 - Okara — the residue from the production of soy milk and tofu — has an unpleasant smell and taste. About 10,000 tonnes of this pulp is produced in Singapore each year. Usually it is discarded by soy food producers as food waste. Now, scientist at the National University of Singapore have devised a process that could allow to use it as nutrient source. read...

Padding for the Winter

The team found that the fruits likely consumed by Dryopithecus at the end of the growth period in early winter from November to December had a high sugar and especially fructose content. This in turn led to the formation of body fat due to the lack of uricase in the metabolism. The conclusion that European great apes had substantial fat reserves was confirmed by the only complete skeleton known to date — that of the eight million year old Oreopithecus bamboli found in Tuscany. In its preserved soft tissue there were closely-packed fat cells, similar in size and shape to those of modern humans.

According to Böhme, many clinical studies have shown that high levels of uric acid in the blood lead to high blood pressure. The uricase theory states that stable higher blood pressure could have been, along with fat reserves, an important selective advantage for apes in Miocene Europe because these conditions enable physical activity even when food is scarce. A mutation which happened millions of years ago is largely responsible for early great apes being able to settle Eurasia and to produce an enormous diversity of species. “We carry that legacy within us. But this advantage has turned into a handicap for us in a world of industrially-produced foodstuffs," Böhme concludes.

Publication: Fuss, J., Uhlig, G., Böhme, M: Earliest evidence of caries lesion in hominids reveal sugar-rich diet for a Middle Miocene dryopithecine from Europe". PLOS ONE, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203307

Melatonin Helps Burn Calories and Reduces Weight Gain

Spain: Hormone Treatment

Melatonin Helps Burn Calories and Reduces Weight Gain

05/15/2018 - Researchers from the University of Granada, University Hospital La Paz (Madrid) and the University of Texas (USA) have identified a new molecular mechanism underlying the anti-obesity effects of the chronic administration of melatonin, a naturally occurring hormone released by the pineal gland overnight. read...

Comments are being loaded ....

Leave a comment

The comment is checked by an editor and will be released soon.

  1. Avatar
    Avatar
    Edited by at
    Edited by at
    1. Avatar
      Avatar
      Edited by at
      Edited by at

Comments are being loaded ....

Report comment

Kommentar Freigeben

Der untenstehende Text wird an den Kommentator gesendet, falls dieser eine Email-hinterlegt hat.

Freigabe entfernen

Der untenstehende Text wird an den Kommentator gesendet, falls dieser eine Email-hinterlegt hat.

copyright

This article is protected by copyright. You want to use it for your own purpose? Infos can be found under www.mycontentfactory.de (ID: 45476930 / Laborpraxis Worldwide)