German China

Czech Republic: Light Scattering Measurement Investigating the Properties of Novel Polymer Nanogels

Editor: MA Alexander Stark

Researchers at Lodz University of Technology (Poland) have combined the advanced analytical capabilities of Testa Analytical Solution's GPC/SEC triple detection system with a BI-200SM light scattering goniometer to derive in-depth information about an exciting new generation of polymer nanogels.

Set-up for static and dynamic light scattering measurement.
Set-up for static and dynamic light scattering measurement.
(Source: Testa Analytical Solutions)

Berlin/Germany — Polymer nanogels with cross-linked structure provide a versatile platform for storage and release of biologically active compounds. They offer a highly desirable method of loading and delivering active forms of drugs or proteins toward cells for remaining activity, enhancing stability, and avoiding potential immunogenicity of proteins. Reported promising applications of polymer nanogels include drug delivery agents, contrast agents for medical imaging, nanoactuators, and sensors.

For over 20 years, the Division of Applied Radiation Chemistry in the Institute of Applied Radiation Chemistry at the Lodz University of Technology has been a leading research center for the synthesis of polymer nanogels.

To advance their characterization capabilities the Division invested in a number of methods to analyze the physico-chemical properties of the polymer nanogels that they synthesize. This includes static and dynamic light scattering using a research grade goniometer and Gel Permeation Chromatography (GPC) with triple detection (MALLS, DRI, Viscometer). Combining these methods, the scientists were able to determine changes in molecular weight and size (or their distribution) during synthesis and to have a full view on interactions between chain segments or macromolecules. According to Dr Slawomir Kadlubowski the Associate Professor of the Division of Applied Radiation Chemistry, this leads not only to the understanding of the mechanism of intramolecular crosslinking, which is a basic reaction for nanogel synthesis, but also to a product with the properties required by a specific practical application such as a drug delivery system. The team chose to purchase the triple detection GPC system and the light scattering goniometer from Testa Analytical not only because of the excellent performance and versatility of their systems but also because of the informed technical support, stated the Professor.

He added: “In future we will also be able to combine light scattering technique with our pulse radiolysis system to follow kinetics of the nanogels synthesis to more deeply analyze mechanism of the reactions taking place during irradiation of aqueous solutions of polymers”.