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Precision Chlorination Rice Chemists Develop Sustainable Chlorine Integration

Source: Rice University 2 min Reading Time

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Chlorine is a quiet hero of modern life, from cleaning pools to crafting essential products like medicines and plastics. Now, Rice University chemists have unveiled a groundbreaking, eco-friendly way to add chlorine to organic molecules using gentle blue light, paving the way for cleaner, more precise, and cost-effective innovations in pharmaceuticals, pesticides, and beyond.

Led by Julian West, researchers developed a photocatalytic process that uses iron and sulfur catalysts activated by mild blue light to add chlorine atoms to organic molecules.(Source: Rice University)
Led by Julian West, researchers developed a photocatalytic process that uses iron and sulfur catalysts activated by mild blue light to add chlorine atoms to organic molecules.
(Source: Rice University)

Chlorine plays an essential part in daily life, from keeping pools clean to preserving food. Now, a team of chemists at Rice University has developed a more environmentally friendly way to integrate chlorine into chemical building blocks for medications, plastics, pesticides and other essential products while reducing costs.

Led by Julian West, assistant professor of chemistry and a Cancer Prevention and Research Institute of Texas (CPRIT) Scholar, the research team developed a photocatalytic process that uses iron and sulfur catalysts activated by mild blue light to add chlorine atoms to organic molecules. This innovation eliminates the need for harsh chemicals or high temperatures typically required in chlorination, which can generate difficult-to-purify byproducts.

“Our method uses sustainable, low-cost catalysts and operates at room temperature with gentle blue light,” West said. “It provides a targeted, efficient way to chlorinate molecules without conventional approaches’ environmental and purification challenges.”

One advantage of the team’s method is its precise targeting of chlorine placement on molecules, a process called anti-Markovnikov hydrochlorination. This precision creates highly pure products by selectively attaching chlorine atoms to less-reactive parts of the starting molecules. With this approach, chemists can avoid extra purification steps that are often time-consuming and costly.

The researchers also unveiled a novel addition to this process: using heavy water to incorporate deuterium, a stable hydrogen isotope. This step could make certain drugs last longer in the body by increasing their stability, potentially enhancing their effectiveness.

“It’s exciting that this method could open new doors for modifying pharmaceuticals and natural products in ways that weren’t possible with older techniques,” West said.

Original Article: Anti-Markovnikov hydro- and deuterochlorination of unsaturated hydrocarbons using iron photocatalysis; Nature Synthesis; DOI:10.1038/s44160-024-00698-z

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