PROCESS Worldwide Article | Nov 20, 2019 PAT is no Magic Trick: How On-Line Sensors Facilitate Help to Ensure “Quality by Design”
PROCESS Worldwide Article | Jun 8, 2018 Continuous Online Measurement of Viable Cell Density for Improved Process Insight
:quality(80)/p7i.vogel.de/wcms/aa/39/aa398d3e6667bdb43ad57abf38dc394c/0129347450v2.jpeg "An illustration shows a strand of engineered DNA passing through a nanoscale sensor, where its physical structure can be decoded as digital information. DNA nanostructures could one day serve as ultra-dense carriers of digital information and advance the field of data encryption. (Source: Jason Drees/ ASU)")
:quality(80)/p7i.vogel.de/wcms/06/a1/06a11f1d752afb35854aa9e1afb62e98/0129209625v2.jpeg "“Unsinkable\" metal tube made from chemically-etched aluminum floats in distilled water at the lab of University of Rochester professor Chunlei Guo. (Source: J. Adam Fenster / University of Rochester)")
:quality(80)/p7i.vogel.de/wcms/6d/df/6ddf023361ec7f8fbfb6c56521577960/0129056554v2.jpeg "The evolution of carburization (depicted by the spheres) under kinetic control (illustrated by the surface contours). The molecular beams represent gas evolution under synthesis conditions while the fiery sphere highlights the formation of the pure tungsten semi-carbide phase with additional molecular beams at the top to illustrate its catalytic performance. (Source: Sinhara M. H. D. Perera)")
:quality(80)/p7i.vogel.de/wcms/26/3d/263d97f8f2797267ecf2781b56882758/0129056451v1.jpeg "A study by the Complexity Science Hub finds that AI systems are already involved in nearly one-third of newly written software code, with rapid adoption in the United States and Europe and measurable productivity gains mainly for experienced developers. (Source: free licensed)")
:quality(80)/p7i.vogel.de/wcms/21/03/21030cc2541c455da0769decca8d1f82/0129146048v2.jpeg "Vyon porous plastics from Porvair Sciences are the perfect material for filtration applications in the healthcare and medical device market. (Source: Porvair Sciences)")
:quality(80)/p7i.vogel.de/wcms/bd/aa/bdaae5b9d381e2471ab37f479ad43d79/0129143884v2.jpeg "The Solvent Line Monitor from Testa Analytical is a true plug-and-play addition to any HPLC system designed to detect when one or more of its pump solvent reservoirs are empty and automatically shut-off the system. (Source: Testa Analytical)")
:quality(80)/p7i.vogel.de/wcms/8f/66/8f66b8acbb3037ca8e6b320bcad1c817/0129118043v2.jpeg "The Plasmaquant 9200 series is ideal for applications in research, trace analysis and quality control. (Source: Analytik Jena )")
:quality(80)/p7i.vogel.de/wcms/66/82/66825163ab842baded640db1a484e729/0129117548v2.jpeg "Biotech Fluidics has announced the Smartsaver solvent recycling unit which is designed to recover up to 90 % of your mobile phase by redirection of the pure solvent to the solvent reservoir during isocratic HPLC. (Source: Biotech Fluidics )")
:quality(80)/p7i.vogel.de/wcms/1a/4f/1a4fe7f8b5541716ba908251738beca1/0129349759v2.jpeg "Krict’s Syngas-to-Sustainable Aviation Fuel (SAF) Conversion Facility (Source: Korea Research Institute of Chemical Technology (Krict))")
:quality(80)/p7i.vogel.de/wcms/d4/29/d429a973c6f14ced3d2eb44931669a78/0129348927v1.jpeg "Cage-like ulva biochar confined synthesis of Fe₃O₄/ZnO heterojunction nanoparticles for synergistic adsorption and photocatalytic degradation of PFOA
(Source: Hua Jing et. al.)")
:quality(80)/p7i.vogel.de/wcms/86/90/8690b8154a552da13b37f289349b1db4/0129283446v2.jpeg "Lina Pérez-Ángel holds two sediment samples whose ages are separated by about a million years. (Source: Ellen Jorgensen)")
:quality(80)/p7i.vogel.de/wcms/90/f8/90f8c3152a59205a7cac1cc182eb186b/0129209634v2.jpeg "Nitrate in drinking water linked to increased dementia risk while nitrate from vegetables is linked to a lower risk, researchers find . (Source: free licensed)")
:quality(80)/p7i.vogel.de/wcms/d1/3c/d13c2ad34af600dbd360c0bb0990b922/0129045715v2.jpeg "Replacing animal products with plant-based foods helps reduce the risk of heart disease and type 2 diabetes, finds a new review by the Physicians Committee for Responsible Medicine. (Source: Pixabay)")
:quality(80)/p7i.vogel.de/wcms/e1/b3/e1b3e26d03101ba93b76b304da150c9a/0129025388v2.jpeg "The research reanalyzed data from a seminal clinical trial, led by US National Institutes of Health veteran Dr Kevin Hall, which first exposed how eating exclusively UPFs results in excessive calorie consumption and weight gain. (Source: Pixabay)")
:quality(80)/p7i.vogel.de/wcms/75/db/75db8afe45607bee750df705e22b60e9/0128938816v1.jpeg "A new academic review suggests that bamboo shoots could offer significant health benefits, including improved blood sugar control, gut health and antioxidant activity. (Source: free licensed)")
:quality(80)/p7i.vogel.de/wcms/85/42/85423f3382c25d1ae0ac5645e969cd36/0128898289v2.jpeg "Dr Arya Gopinath Madathil Pulikkal (left) and Asst Prof Andy Tay (right) in front of a small greenhouse containing Choy Sum plants. (Source: NUS)")
:quality(80)/p7i.vogel.de/wcms/0d/9b/0d9bcd7e41846276db862456d619edd2/0129351002v2.jpeg "A Caltech-led team has developed a way of making bubble bots with simple protein shells that can be modified by enzymes or magnetic nanoparticles for efficient drug delivery. One version the researchers has made is \"smart\" enough to direct itself to direct itself to a tumor target. (Source: Gao Lab/ Caltech)")
:quality(80)/p7i.vogel.de/wcms/1a/ee/1aee2613e1a69c73ab568ee61d354ded/0129347044v1.jpeg "The Tonks lab studied PTP1B inhibition in a mouse model of Alzheimer’s disease. When PTP1B was deleted, as shown in the bottom row, the brain’s immune cells (green) were better at engulfing harmful amyloid-β plaques (grey), as shown in the left column. (Source: Nicholas Tonks/ CSHL)")
:quality(80)/p7i.vogel.de/wcms/fe/b7/feb7e0d151036b0c2be071e958dbce3b/0129341435v2.jpeg "As youth mental health challenges have risen alongside increased social media use, researchers and policymakers have questioned whether platforms contribute to emotional distress. (Source: Pixabay)")
:quality(80)/p7i.vogel.de/wcms/88/a9/88a9b2ab395cbc322811baef39346455/0129321685v2.jpeg "Researchers have succeeded in identifying biomarkers for Parkinson’s disease in its earliest stages, before extensive brain damage has occurred. (Source: Nicola Pietro Montaldo)")
:quality(80)/images.vogel.de/vogelonline/bdb/1710600/1710675/original.jpg "Discover how to set yourself up for success when performing balance-based density determination of solids such as jewelry and precious metals. (Mettler Toledo)")
:quality(80)/images.vogel.de/vogelonline/bdb/1682500/1682579/original.jpg "The new XPR Analytical balance redesigned to meet the needs of laboratory technicians of working fast and lean. (Mettler Toledo)")
:quality(80)/images.vogel.de/vogelonline/bdb/1677000/1677080/original.jpg "Enhance your weighing accuracy, comfort and productivity with the redesigned XPR Analytical balance. (Mettler Toledo)")
:quality(80):fill(ffffff,1)/p7i.vogel.de/wcms/2c/4d/2c4d6a131aec70fbbbc88360d3d52b27/91209050.jpeg?v= "Computers and mobile devices equipped with Arc Air software can communicate wirelessly with up to 31 sensors and streamline configuration, calibration, and other common workflows. (Source: Hamilton)")
![The FDA’s PAT framework calls for in-line process sensors that can move a measurement from manual sampling and laboratory instruments to automated control. (Hamilton; ©ra2 studio - stock.adobe.com; [M]Grimm)](https://cdn1.vogel.de/bnBDxDOX_3ILGLJ4cPD9q39USKk=/fit-in/320x180/filters:format(jpg):quality(80):fill(ffffff,1)/images.vogel.de/vogelonline/bdb/1645800/1645802/original.jpg?v= "The FDA’s PAT framework calls for in-line process sensors that can move a measurement from manual sampling and laboratory instruments to automated control. (Hamilton; ©ra2 studio - stock.adobe.com; [M]Grimm)")
![Breaking new ground in bioprocessing: Viable cells behave like little capacitors. In an alternating electrical field their polarization and depolarization can be measured and the signal can be correlated to the bio-volume, resp. the viable cell density. Because only viable cells can be polarized, this method is insensitive to cell debris as well as to microcarriers. (©Paulista; ©gonin - stock.adobe.com; Hamilton [M]GötzelHorn)](https://cdn1.vogel.de/wK1cGCZHsN3R3v6O7K8UrHdCYaQ=/fit-in/320x180/filters:format(jpg):quality(80):fill(ffffff,1)/images.vogel.de/vogelonline/bdb/1408400/1408402/original.jpg?v= "Breaking new ground in bioprocessing: Viable cells behave like little capacitors. In an alternating electrical field their polarization and depolarization can be measured and the signal can be correlated to the bio-volume, resp. the viable cell density. Because only viable cells can be polarized, this method is insensitive to cell debris as well as to microcarriers. (©Paulista; ©gonin - stock.adobe.com; Hamilton [M]GötzelHorn)")