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German China

Greener, Revolutionary Method for Producing Grignard Reagents

(Left) Reaction mixture of magnesium metal and organohalide after one hour of ball milling. Use of this material in subsequent reactions led to only a 6 % yield of the desired product. (Right) Same process, but with a small amount of organic solvent also added at the beginning. Use of this paste form of Grignard reagent in subsequent reactions led to yields of up to 94 % of the desired product. (Koji Kubota) Image Zoom
(Left) Reaction mixture of magnesium metal and organohalide after one hour of ball milling. Use of this material in subsequent reactions led to only a 6 % yield of the desired product. (Right) Same process, but with a small amount of organic solvent also added at the beginning. Use of this paste form of Grignard reagent in subsequent reactions led to yields of up to 94 % of the desired product. (Koji Kubota)
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