Greener, Revolutionary Method for Producing Grignard Reagents
(Left) Reaction mixture of magnesium metal and organohalide after one hour of ball milling. Use of this material in subsequent reactions led to only a 6 % yield of the desired product. (Right) Same process, but with a small amount of organic solvent also added at the beginning. Use of this paste form of Grignard reagent in subsequent reactions led to yields of up to 94 % of the desired product.
(Picture: Koji Kubota)
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/cdn4.vogel.de/infinity/white.jpg "(Left) Reaction mixture of magnesium metal and organohalide after one hour of ball milling. Use of this material in subsequent reactions led to only a 6 % yield of the desired product. (Right) Same process, but with a small amount of organic solvent also added at the beginning. Use of this paste form of Grignard reagent in subsequent reactions led to yields of up to 94 % of the desired product. (Koji Kubota)")
