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Gut Health Meets Gene Health Why You Should Eat More Fiber: Insights Into Genetic and Anti-Cancer Impact

Source: Stanford Medicine 2 min Reading Time

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A groundbreaking Stanford Medicine study uncovers how fiber-rich foods like beans, nuts and avocados directly influence gene expression with anti-cancer effects. Published in Nature Metabolism, the research highlights how gut microbiome byproducts from fiber digestion may play a crucial role in preventing and controlling cancer.

Scientists found a direct link between eating fiber and modulation of gene function.(Source: free licensed / Pixabay)
Scientists found a direct link between eating fiber and modulation of gene function.
(Source: free licensed / Pixabay)

Fiber is well known to be an important part of a healthy diet, yet less than 10 % of Americans eat the minimum recommended amount. A new study from Stanford Medicine might finally convince us to fill our plates with beans, nuts, cruciferous veggies, avocados and other fiber-rich foods. The research, which will be published in Nature Metabolism on Jan. 9 identified the direct epigenetic effects of two common byproducts of fiber digestion and found that some of the alterations in gene expression had anti-cancer actions.

When we eat fiber, the gut microbiome produces short-chain fatty acids. These compounds are more than just an energy source for us: They have long been suspected to indirectly affect gene function. The researchers traced how the two most common short-chain fatty acids in our gut, propionate and butyrate, altered gene expression in healthy human cells, in treated and untreated human colon cancer cells, and in mouse intestines. They found direct epigenetic changes at specific genes that regulate cell proliferation and differentiation, along with apoptosis, or pre-programmed cell death processes — all of which are important for disrupting or controlling the unchecked cell growth that underlies cancer.

“We found a direct link between eating fiber and modulation of gene function that has anti-cancer effects, and we think this is likely a global mechanism because the short-chain fatty acids that result from fiber digestion can travel all over the body,” said Michael Snyder, PhD, Stanford W. Ascherman, MD, Facs Professor in Genetics. “It is generally the case that people’s diet is very fiber poor, and that means their microbiome is not being fed properly and cannot make as many short-chain fatty acids as it should. This is not doing our health any favors.”

Given the worrying rates of colon cancer in younger adults, the study findings could also spur conversation and research about the possible synergistic effects of diet and cancer treatment.

“By identifying the gene targets of these important molecules we can understand how fiber exerts its beneficial effects and what goes wrong during cancer,” Snyder added.

Original Article: Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression; Nature Metabolism; DOI:10.1038/s42255-024-01191-9

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