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Chip Reader Blocks Effective, Controlled Turbulent Mixing for Flow Chemistry

Editor: MA Alexander Stark

The Uniqsis range of Glass Static Mixer (GSM) chip reactor blocks produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent.

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Hotchip module fitted with GSM chip adapter.
Hotchip module fitted with GSM chip adapter.
(Source: Uniqsis)

To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions

Now available in sizes from 270 µl to 20 ml, the recently expanded range of GSM chips from Uniqsis can be used to perform reactions from -80 °C to over 150 °C. GSM chips up to 2 ml can be operated up to 40 bar and are available in 2-channel or 3-channel inlet configurations. Larger GSM chips of 10 ml and 20 ml have a premixing channel followed by a residence domain and can operate up to 10 bar.

GSM chips can be used as mixing modules prior to a coil reactor residence time unit, or as reactor blocks for rapid exothermic reactions such nitration’s. Nitration is an important synthetic procedure that, following reduction of the nitro group, provides a useful route for the introduction of amino groups onto aromatic rings. Uniqsis' Application Note 22 describes how a GSM chip was used to control both temperature and mixing. Under these controlled conditions, selective mono-nitration was rapidly performed at elevated temperature to maximise throughput.

These types of chips are precision machined from inert borosilicate glass to withstand a wide temperature range and can be conveniently attached to a Flowsyn column heater module, Cold Coil or Polar Bear Plus cryogenic reactor modules.