Defined Hydrogel Enables Reproducible Culture of Cancer Cells in Xenograft Models

ECM Hydrogel Defined Hydrogel Enables Reproducible Culture of Cancer Cells in Xenograft Models

2025-02-10 Source: Press release Amsbio 1 min Reading Time

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Amsbio has introduced Matrimix for PDX, a fully defined extracellular matrix hydrogel which comprises of collagen, laminin-511 E8 fragments and hyaluronic acid. The defined hydrogel has been optimized to support patient-derived xenograft studies.

Vascular formation in tumor tissue cultured in Matrimix for PDX (endothelial cell marker, purple).(Source: Amsbio) — Vascular formation in tumor tissue cultured in Matrimix for PDX (endothelial cell marker, purple).
(Source: Amsbio)

Amsbio has launched Matrimix for PDX, a fully defined extracellular matrix (ECM) hydrogel comprising of collagen, laminin-511 E8 fragments and hyaluronic acid optimized to support patient-derived xenograft (PDX) studies.

A PDX model uses a patient's tumor tissue to create a growing tumor in an immunodeficient mouse. They retain the histological and genetic characteristics of the patient’s original tumor, offering a superior platform for studying cancer biology and drug responses, allowing researchers to develop new treatments through drug screening and toxicology studies, shares the company.

Comprising a mixture of fully defined collagen type I, laminin-511 E8 fragments, and hyaluronic acid, the ECM hydrogel for PDX is a ready-to-use 3D culture substrate product optimized for culturing patient derived cancer cells. Proven to facilitate excellent cell organization and accurately replicate in vivo conditions, Matrimix for PDX is the ultimate solution for culturing even difficult-to-grow cancer cell types as xenograft, adds the firm. The high lot-to-lot consistency of the ECM hydrogel for PDX enables researchers to routinely obtain highly reproducible results.

The types and concentrations of the individual components in Matrimix for PDX have been optimized to provide an optimal extracellular environment for target cells. According to the company, through its use of medical grade porcine collagens, the ECM hydrogel for PDX streamlines the transition from basic to clinical research unlike any existing natural hydrogel.

Supplied frozen, Matrimix for PDX transitions to a clear gel when warmed to physiological temperature (37⁰C). This feature allows superior visualization possibilities, making it valuable for applications requiring real-time monitoring of tumor growth, invasion, and drug response assays. The ECM hydrogel for PDX comes as a single, all-in-one vial, opines the firm. Matrimix is also available in a tunable three-vial format, allowing end-users to optimize for their specific 3D Cell Culture or organoid models.

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Date: 08.12.2025

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