UK: iPSC-Derived Microglia Axol Bioscience Developed New Stem Cell Type for Treatment of Neurodegenerative Diseases
Editor: Alexander Stark
Axol Bioscience is launching a new line of Human induced Pluripotent Stem Cells (iPSC)-derived Microglia for the consistent and reproducible study of neuroglia and their involvement in neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis and Parkinson’s disease.
Microglia are commonly described as the immune cells of the brain, with key roles in brain development, neurogenesis, synaptic plasticity and homeostatic maintenance.
(Source: Axol Bioscience)
Cambridge/UK — Microglia are commonly described as the immune cells of the brain. Human iPSC-derived Microglia offer scientists the opportunity to integrate this clinically important cell type into their in vitro models and assays of neurogenesis and neurodegeneration. Axol generates physiologically relevant Human iPSC-derived Microglia from a single donor with a normal karyotype, providing a homogenous population that is assay-ready in just four days.
The variability associated with traditional microglia cell lines, together with limited availability, poses significant challenges for pharmaceutical and biotech companies developing novel therapeutics to treat neurodegenerative diseases. Yichen Shi, Chief Executive Officer, Axol Bioscience argues that the launch of Human iPSC-derived Microglia would provide scientists with a reproducible, physiologically relevant model in an easy-to-use, assay-ready format for investigating neuroglia involvement in neurodegeneration and neurodevelopment.
The homogenous and reproducible population of the Human iPSC-derived Microglia exhibits physiologically relevant functionality with highly phagocytic activity and secretion of cytokines in response to pathogens. Axol’s Human iPSC-derived Microglia also express the microglia-specific marker Transmembrane protein 119 (TMEM119) along with myeloid markers Triggering Receptor Expressed on Myeloid cells 2 (TREM2) and Ionised Calcium Binding Adaptor molecule-1 (IBA-1). The expression of these phenotypes means the Microglia provide a suitable model for investigating neuroinflammation in Alzheimer’s disease, multiple sclerosis and Parkinson’s disease.
Unfold for details of your consent
Stand vom 23.03.2021
Naturally, we always handle your personal data responsibly. Any personal data we receive from you is processed in accordance with applicable data protection legislation. For detailed information please see our privacy policy.
Consent to the use of data for promotional purposes
I hereby consent to Vogel Communications Group GmbH & Co. KG, Max-Planckstr. 7-9, 97082 Würzburg including any affiliated companies according to §§ 15 et seq. AktG (hereafter: Vogel Communications Group) using my e-mail address to send editorial newsletters. A list of all affiliated companies can be found here
Newsletter content may include all products and services of any companies mentioned above, including for example specialist journals and books, events and fairs as well as event-related products and services, print and digital media offers and services such as additional (editorial) newsletters, raffles, lead campaigns, market research both online and offline, specialist webportals and e-learning offers. In case my personal telephone number has also been collected, it may be used for offers of aforementioned products, for services of the companies mentioned above, and market research purposes.
In case I access protected data on Internet portals of Vogel Communications Group including any affiliated companies according to §§ 15 et seq. AktG, I need to provide further data in order to register for the access to such content. In return for this free access to editorial content, my data may be used in accordance with this consent for the purposes stated here.
Right of revocation
I understand that I can revoke my consent at will. My revocation does not change the lawfulness of data processing that was conducted based on my consent leading up to my revocation. One option to declare my revocation is to use the contact form found at https://support.vogel.de. In case I no longer wish to receive certain newsletters, I have subscribed to, I can also click on the unsubscribe link included at the end of a newsletter. Further information regarding my right of revocation and the implementation of it as well as the consequences of my revocation can be found in the data protection declaration, section editorial newsletter.
:quality(80)/p7i.vogel.de/wcms/87/78/8778c95da1a93c577b8ee63b89a9ea92/0105379690.jpeg "0105379690")
:quality(80)/p7i.vogel.de/wcms/ec/71/ec71bc17999b7c321892010fe023712b/0105339441.jpeg "0105339441")
:quality(80)/p7i.vogel.de/wcms/44/d7/44d72fef6e90321f370e563387cd427d/0105332698.jpeg "0105332698")
:quality(80)/p7i.vogel.de/wcms/5b/59/5b59459138da72c4101f55d6a1f5d6e9/0105296253.jpeg "0105296253")
:quality(80)/p7i.vogel.de/wcms/b1/53/b153013223a2288a96d789b1a70735c9/0105419200.jpeg "0105419200")
:quality(80)/p7i.vogel.de/wcms/4e/2a/4e2a144319130f1f0c04813c371f0939/0105291950.jpeg "0105291950")
:quality(80)/p7i.vogel.de/wcms/6a/65/6a6510b5ec7cb55ae4d825798f9d7f21/0105162306.jpeg "0105162306")
:quality(80)/p7i.vogel.de/wcms/b4/b6/b4b6d220aabd3340cd195449d6e6086e/0105234071.jpeg "0105234071")
:quality(80)/p7i.vogel.de/wcms/09/44/0944a2cfbe9b84e0ebd699e0770817df/0105068313.jpeg "0105068313")
:quality(80)/p7i.vogel.de/wcms/25/e0/25e03fe398377396b773b00f17b4b81e/0105058832.jpeg "0105058832")
:quality(80)/p7i.vogel.de/wcms/5f/cb/5fcb52d64a4963e20764893ee85b2ebb/0105025395.jpeg "0105025395")
:quality(80)/p7i.vogel.de/wcms/4d/b2/4db210ba4bc55954c41c2154d375d909/0105010131.jpeg "0105010131")
:quality(80)/p7i.vogel.de/wcms/0d/3b/0d3b418adb4c7af71022c52878dd8fdf/0104800005.jpeg "0104800005")
:quality(80)/images.vogel.de/vogelonline/bdb/1963700/1963732/original.jpg)
:quality(80)/images.vogel.de/vogelonline/bdb/1963500/1963506/original.jpg "Healthy adults eating a diverse diet with at least eight to ten grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts. Soluble fiber is found in foods such as grains, beans, lentils, nuts, and some fruits and vegetables.")
:quality(80)/images.vogel.de/vogelonline/bdb/1963400/1963459/original.jpg "Thermo Scientific Dionex Ionpac CS21-Fast-4m ion exchange column.")
:quality(80)/p7i.vogel.de/wcms/c2/8d/c28d67c9b76f30205e80e2826942060a/0105389353.jpeg "0105389353")
:quality(80)/p7i.vogel.de/wcms/c0/5d/c05d1614f8d9f488c68a6a681e16d0d9/0105371581.jpeg "0105371581")
:quality(80)/p7i.vogel.de/wcms/94/c8/94c8112fdd1958527b65b3300c61f0c0/0105334243.jpeg "0105334243")
:quality(80)/p7i.vogel.de/wcms/d8/af/d8af4986f811d0eb921cfcb130eea516/0105309677.jpeg "0105309677")
:quality(80)/images.vogel.de/vogelonline/bdb/1710600/1710675/original.jpg "Discover how to set yourself up for success when performing balance-based density determination of solids such as jewelry and precious metals.")
:quality(80)/images.vogel.de/vogelonline/bdb/1682500/1682579/original.jpg "The new XPR Analytical balance redesigned to meet the needs of laboratory technicians of working fast and lean.")
:quality(80)/images.vogel.de/vogelonline/bdb/1677000/1677080/original.jpg "Enhance your weighing accuracy, comfort and productivity with the redesigned XPR Analytical balance.")
:quality(80)/images.vogel.de/vogelonline/bdb/1491900/1491901/original.jpg "Zika is a Flavivirus transmitted primarily by the Aedes mosquito.")
:quality(80)/images.vogel.de/vogelonline/bdb/1963400/1963429/original.jpg "The new study describes the implantation of induced pluripotent stem cells to replace dopamine-producing neurons destroyed by Parkinson's disease.")
:quality(80)/images.vogel.de/vogelonline/bdb/1826600/1826618/original.jpg "Imec’s chip technology instrumental is decoding brain diseases. By growing relevant circuits on chip, the mechanisms behind Parkinson’s can be unraveled.")